Identification and Synthesis of Major Impurities Formed During the Synthesis of Trifloxystrobin and Kresoxim-methyl Fungicides

Author(s): Pasumpon Kamaraj, Nakita Antao, Apoorva Singh, Vijay Satam, Subhash Kadam, Venkatesh M. Prabhu, Rama Mohan Hindupur, Hari N. Pati.

Journal Name: Letters in Organic Chemistry

Volume 12 , Issue 5 , 2015

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Abstract:

During process development of Trifloxystrobin and Kresoxim-methyl fungicides, two impurities were identified. These impurities were isolated and characterized using LCMS, IR, 1H NMR, 13C NMR and elemental analysis. Structures of the impurities were further unambiguously confirmed by their independent synthesis. Structure of both impurities revealed that they possess methyl (E)-methoxyiminoacetate pharmacophore, responsible for antifungal activities of strobilurins, in combination with arylmethyl (E)-methoxyiminoacetate framework.

Keywords: Fungicide, impurities, Kresoxim-methyl, pharmacophore, strobilurins, Trifloxystrobin.

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Article Details

VOLUME: 12
ISSUE: 5
Year: 2015
Page: [306 - 310]
Pages: 5
DOI: 10.2174/1570178612666150318002831
Price: $65

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