Title:Synthesis, Antimicrobial, Anticancer Evaluation of 2-(aryl)-4- Thiazolidinone Derivatives and their QSAR Studies
VOLUME: 15 ISSUE: 11
Author(s):Aakash Deep, Pradeep Kumar, Balasubramanian Narasimhan, Kalavathy Ramasamy, Vasudevan Mani, Rakesh Kumar Mishra and Abu Bakar Abdul Majeed
Affiliation:Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India.
Keywords:4-Thiazolidinones, Antibacterial, Anticancer, Antifungal, QSAR, Synthesis.
Abstract:A new class of 4-thiazolidinones clubbed with quinozolinone nucleus has been synthesized.
The title compounds were screened for their in vitro antimicrobial and anticancer potentials. Results of
antimicrobial and anticancer study revealed that compounds 7 (pMICam = 1.69 μM/ml) and 2 (IC50 =
12.83 μM) were found to be the most potent antimicrobial and anticancer agents respectively. QSAR
studies indicated that antimicrobial activity of synthesized 4-thiazolidinone derivatives was governed by the electronic parameters,
dipole moment (μ), energy of highest occupied molecular orbital (HOMO), lipophilic parameter, log P and topological
parameter, valence third order molecular connectivity index (3χv).
