Synthesis, Antimicrobial, Anticancer Evaluation of 2-(aryl)-4- Thiazolidinone Derivatives and their QSAR Studies

Author(s): Aakash Deep, Pradeep Kumar, Balasubramanian Narasimhan, Kalavathy Ramasamy, Vasudevan Mani, Rakesh Kumar Mishra, Abu Bakar Abdul Majeed.

Journal Name: Current Topics in Medicinal Chemistry

Volume 15 , Issue 11 , 2015

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Graphical Abstract:


A new class of 4-thiazolidinones clubbed with quinozolinone nucleus has been synthesized. The title compounds were screened for their in vitro antimicrobial and anticancer potentials. Results of antimicrobial and anticancer study revealed that compounds 7 (pMICam = 1.69 μM/ml) and 2 (IC50 = 12.83 μM) were found to be the most potent antimicrobial and anticancer agents respectively. QSAR studies indicated that antimicrobial activity of synthesized 4-thiazolidinone derivatives was governed by the electronic parameters, dipole moment (μ), energy of highest occupied molecular orbital (HOMO), lipophilic parameter, log P and topological parameter, valence third order molecular connectivity index (3χv).

Keywords: 4-Thiazolidinones, Antibacterial, Anticancer, Antifungal, QSAR, Synthesis.

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Article Details

Year: 2015
Page: [990 - 1002]
Pages: 13
DOI: 10.2174/1568026615666150317221849
Price: $58

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