Pattern Recognition by CD6: A Scavenger-Like Lymphocyte Receptor

Author(s): Adelaida Sarukhan, Mario Martinez-Florensa, Cristina Escoda-Ferran, Esther Carrasco, Esther Carreras, Francisco Lozano.

Journal Name: Current Drug Targets

Volume 17 , Issue 6 , 2016

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Abstract:

CD6, one of the first antigens to be identified on T cells, is a membrane glycoprotein that physically associates with the antigen receptor complex. Because of this, its main function seems to involve the modulation of TCR-mediated signaling pathways. However, growing evidence indicates that this ancient and conserved scavenger-like receptor may also play a role as pattern recognition receptor (PRR), similar to other members of the scavenger receptor cysteine rich superfamily (SRCR-SF). Here, we discuss the functional interactions of CD6 with microbe- and damage-associated signals and the potential use of soluble forms of CD6 in the therapeutic treatment of bacterial infections, in particular multi-drug resistant bacterial strains. Importantly, microbe recognition by CD6 may also have functional consequences on T cell activation and differentiation, which remain to be explored.

Keywords: Bacteria, CD5, CD6, lipopolysaccharide, lipoteichoic acid, pathogen-associated molecular patterns (PAMPs), pattern- recognition receptor (PRR), peptidoglycan, scavenger receptor cysteine-rich (SRCR).

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Article Details

VOLUME: 17
ISSUE: 6
Year: 2016
Page: [640 - 650]
Pages: 11
DOI: 10.2174/1389450116666150316224308
Price: $58

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