In different inflammatory diseases, many metalloproteinases are over expressed and
thought to promote progression of the disease. Understanding roles of these enzymes in disease
progression as well as in normal homeostasis is crucial to identify target enzymes for the disease.
Rheumatoid arthritis (RA) is one of the autoimmune inflammatory diseases in which around 1-2 % of
the world populations are suffered from. Roles of metalloproteinases are well documented in RA, but
so far none of them is proposed to be a target enzyme. However, there are at least three enzymes that
can potentially be molecular targets to inhibit progression of RA. Understanding roles of these
enzymes in more detail and developing highly selective inhibitors to these enzymes would be essential for novel antimetalloproteinase
therapies in future.
Keywords: ADAM, ADAMTS, metalloproteinase, MMP, RA.
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