Animal Models of Systemic Sclerosis

Author(s): Florence Morin , Niloufar Kavian , Frederic Batteux .

Journal Name: Current Pharmaceutical Design

Volume 21 , Issue 18 , 2015

Abstract:

Systemic sclerosis is a systemic connective tissue disorder characterized by the fibrosis of the skin and certain visceral organs, vasculopathy, and immunological abnormalities. Several genetic and inducible animal models of SSc have been developed and are available for research studies. The purpose of this review is to summarize the various animal models of systemic sclerosis and describe the various contributions of these models in terms of understanding the pathophysiology of the condition and searching for new therapeutic strategies for this incurable disease.

Keywords: Systemic sclerosis, fibrosis, vasculopathy, auto-immunity, mice, transgenic, knock-out, topoisomerase-1.

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Article Details

VOLUME: 21
ISSUE: 18
Year: 2015
Page: [2365 - 2379]
Pages: 15
DOI: 10.2174/1381612821666150316120338
Price: $58

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