Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents
Prasanna A. Datar,
Saleel A. Limaye.
Mannich bases were selected for 2D QSAR study to derive meaningful relationship
between the structural features and analgesic activity. Using the knowledge of important
features a novel series was designed to obtain improved analgesic activity. A series of
novel Mannich bases 1-(N-substituted amino)methyl]-2-substituted benzimidazole derivatives
were synthesized and were screened for analgesic activity. Some of these compounds
showed promising analgesic activity when compared with the standard drug diclofenac sodium.
Keywords: Analgesic activity, Mannich bases, N1-substituted benzimidazoles.
Rights & PermissionsPrintExport