Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents)

Bahar Tunctan
Department of Pharmacology
Faculty of Pharmacy
Mersin University
Mersin, 33169


Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents

Author(s): Prasanna A. Datar, Saleel A. Limaye.


Mannich bases were selected for 2D QSAR study to derive meaningful relationship between the structural features and analgesic activity. Using the knowledge of important features a novel series was designed to obtain improved analgesic activity. A series of novel Mannich bases 1-(N-substituted amino)methyl]-2-substituted benzimidazole derivatives were synthesized and were screened for analgesic activity. Some of these compounds showed promising analgesic activity when compared with the standard drug diclofenac sodium.

Keywords: Analgesic activity, Mannich bases, N1-substituted benzimidazoles.

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Article Details

Year: 2015
Page: [35 - 46]
Pages: 12
DOI: 10.2174/1871523014666150312164625