A short overview of fundamental chemistry of lutetium and of structural characteristics of
lutetium coordination complexes, as relevant for understanding the properties of lutetium-177 radiopharmaceuticals,
is presented. This includes basic concepts on lutetium electronic structure, lanthanide
contraction, coordination geometries, behavior in aqueous solution and thermodynamic stability.
An illustration of the structure and binding properties of the most important chelating agents for the
Lu3+ ion in aqueous solution is also reported with specific focus on coordination complexes formed
with linear and macrocyclic polydentate amino-carboxylate donor ligands.
Keywords: Bifunctional chelators, chemistry of lutetium, DOTA, DTPA, lanthanides, Lutetium, lutetium-177
radiopharmaceuticals, lutetium-177, NOTA.
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