N-Aryl-5-aminopyrazole: A Versatile Architecture in Medicinal Chemistry

Author(s): Maura Marinozzi, Gloria Marcelli, Andrea Carotti.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 15 , Issue 4 , 2015

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Abstract:

N-Aryl-5-aminopyrazole represents a key structural motif in a plethora of biologically active molecules endowed with a wide spectrum of pharmacological properties. Accordingly, this scaffold can be certainly included in the category of a privileged structure. As an example, N-aryl-5- aminopyrazole along with its 5-ureido derivatives are recurrent scaffolds in the field of inhibition of the different members of mitogen-activated protein kinases (MAPKs). Over the past recent years a large number of papers highlighting the design, synthesis and biological evaluation of different classes of N-aryl-5-aminopyrazole-containing compounds have been reported in the literature, but a review on this topic is still missing. With the aim to fill this gap, the present review article focuses on the recent developments (1995-mid2014) on the application of the N-aryl-5-aminopyrazole-based compounds in different therapeutic fields, with a particular attention to the design and structure-activity relationships (SAR) aspects of each class of compounds.

Keywords: Biologically active compounds, nitrogen-heterocycle, pyrazole, privileged structure.

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Article Details

VOLUME: 15
ISSUE: 4
Year: 2015
Page: [272 - 299]
Pages: 28
DOI: 10.2174/1389557515666150312154536
Price: $58

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