In-silico Analyses of Natural Products on Leishmania Enzyme Targets

Author(s): L. Scotti, H. Ishiki, F.J.B. Mendonca, M.S. Da Silva, M.T. Scotti.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 15 , Issue 3 , 2015

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Natural products are compounds that are isolated from plants, provide a variety of lead structures for the development of new drugs by the pharmaceutical industry. The interest in these substances increases because of their beneficial effects on human health, which include antiviral, antiallergic, antiplatelet, anti-inflammatory, antitumor, antioxidant, and antiparasitic activities. Leishmaniasis is the infection caused by protozoa of the genus Leishmania, which affects mainly people who live in poor countries, and can cause chronic fever, liver problems, anemia, and other blood problems. Current chemotherapies against the disease cause side effects, and are ineffective. There are no vaccines, and new chemotherapeutic agents for the treatment of leishmaniasis are greatly needed. This work reports on some of the enzymatic targets studied in the development of new drugs using natural products as inhibitors for the treatment of leishmaniasis. We applied ligand-based-virtual screening using Random Forest, associated with structure-based-virtual screening (docking), of a small dataset of 683 flavonoids and derivatives from an in-house data bank to select structures with potential inhibitory activity against pyruvate kinase, an important enzyme in Leishmania mexicana’s energy production chemistry. The computer-aided drug design studies revealed good results against Leishmaniasis for flavones.

Keywords: Docking, enzyme, Leishmania, natural products, Random Forest, target.

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Article Details

Year: 2015
Page: [253 - 269]
Pages: 17
DOI: 10.2174/138955751503150312141854
Price: $58

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