Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors from the Natural Origin: A Recent Perspective
Harun M. Patel,
Overexpression of epidermal growth factor receptor (EGFR) is seen in a number of human tumors like
prostate, colon, breast and ovarian. Their expression is correlated with vascularity and often difficult to diagnose.
Though a number of active inhibitors and anticancer drugs against EGFR-tyrosine kinase are known, increase in
resistance together with many side effects designate the need for new and improved treatments. Natural products
and their analoges have significant contribution in the cancer drug discovery and development process. Therefore in
the current review we mainly discuss design, synthesis and structural activity relationship of epidermal growth
factor receptor (EGFR) tyrosine kinase inhibitors from the natural origin.
Keywords: Epidermal growth factor receptor, Natural origin, SAR.
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