The Horner-Wadsworth-Emmons reaction is one of the most reliable and widespread synthetic tools for
the stereocontrolled construction of ethylenic bonds. The versatility of the reaction makes it a valuable synthetic
tool to prepare simple as well as densely functionalized and complex molecular scaffolds. This review is devoted to
the recent evolution of the reaction, which considerably widens its product scope and synthetic potential. The main
recent developments on the HWE reaction presented in this work comprise novel phosphonate reagents and sequential
reactions involving the HWE olefination. Interesting applications, including access to challenging or complex
synthetic targets, relevant organic compounds and natural products are also highlighted.
Keywords: Horner-Wadsworth-Emmons reaction, carbonyl olefinations, functionalized phosphonate reagents, functionalized olefins, one-pot
reactions, tandem reactions.
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