Biological Agents in Familial Mediterranean Fever Focusing on Colchicine Resistance and Amyloidosis

Author(s): Betul Sozeri, Ozgur Kasapcopur.

Journal Name: Current Medicinal Chemistry

Volume 22 , Issue 16 , 2015

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Abstract:

Familial Mediterranean fever (FMF) is the most common hereditary autoinflammatory syndrome. FMF is caused by mutations in the MEFV gene which encodes the pyrin protein. FMF is characterized by sporadic, paroxysmal attacks of fever and serosal inflammation, lasting 1-3 days. Patients may develop renal amyloidosis. Colchicine prevents attacks and renal amyloidosis.5% to 10% of the patients with FMF are resistant or intolerant to colchicine. Colchicine resistant patients may receive biological therapies. Anti-interleukin-1 drugs are the most important agents of biological treatments. In this review, colchicine resistance and treatment options will be evaluated.

Keywords: Colchicine resistance, Familial Mediterranean fever, therapy.

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Article Details

VOLUME: 22
ISSUE: 16
Year: 2015
Page: [1986 - 1991]
Pages: 6
DOI: 10.2174/0929867322666150311152300
Price: $58

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