Histamine and histamine receptors are well known for their immunomodulatory role in inflammation.
In this review we describe the role of histamine and histamine H4 receptor on human eosinophils.
In the first part of article we provide short summary of histamine and histamine receptors role
in physiology and histamine related therapeutics used in clinics. We briefly describe the human histamine
receptor H4 and its ligands, as well as human eosinophils. In the second part of the review we
provide detailed description of known histamine effects on eosinophils including: intracellular calcium
concentration flux, actin polymerization, cellular shape change, upregulation of adhesion proteins and
cellular chemotaxis. We provide proofs that these effects are mainly connected with the activation of histamine H4 receptor.
When examining experimental data we discuss the controversial results and limitations of the studies performed on
isolated eosinophils. In conclusion we believe that studies on histamine H4 receptor on human eosinophils can provide interesting
new biomarkers that can be used in clinical studies of histamine receptors, that in future might result in the development
of new strategies in the treatment of chronic inflammatory conditions like asthma or allergy, in which eosinophils
Keywords: Cell shape change, chemotaxis, eosinophils, histamine, histamine H4 receptor, H4 receptor ligands, immune system,
Rights & PermissionsPrintExport