Antimicrobial peptides (AMPs) are an heterogeneous group of small amino acidic molecules
produced by the innate immune system of a variety of organisms encompassing all orders of life
from eukaryotes to amphibians, insects and plants. Numerous AMPs have been isolated from natural
sources and many others have been de novo designed and synthetically produced. AMPs have antimicrobial
activity in the micromolar range and compared with traditional antibiotics, they kill bacteria
very rapidly. They act, principally, by the electrostatic attraction to negatively charged bacterial cells and consequently
membrane disruption, but their antibacterial activity may also involve interference with metabolic processes or different
cytoplasmic targets. AMPs are a group of unique and incredible compounds that may be directed to a therapeutic use either
alone or in combination with existing antibiotics.
Keywords: Amphipathic α-helical peptides, antimicrobial peptide, conformational flexibility, multidrug-resistant strain.
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