Evaluation of Urinary Interleukin-8 Levels in Patients with Spinal Cord Injury

Author(s): Monireh Rahimkhani, Alireza Mordadi, Sajad Varmazyar, Ali Tavakoli.

Journal Name: Recent Patents on Anti-Infective Drug Discovery

Volume 9 , Issue 2 , 2014

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Abstract:

Background: Interleukins are a group of cytokines responsible for regulating inflammatory and infectious responses. Interleukin-8 plays an important role in chemotaxis and functioning of leukocytes and is locally produced in infected tissues; it is seen in abundance in the urine of individuals with Urinary Tract Infection.

Material & Methods: Midstream sterile urine sampling was performed in different patients admitted to the Spinal Cord Injury (SCI) research center. The samples were tested to determine the level of IL-8 through the ELISA method. The commercial kit used for this study was an R & D kit built in Germany.

Results: The mean level of IL-8 was 369.59pg/ml and 75.42pg/ml in male and female patients respectively. Among the 97 patients under study, 87 (89.7%) were IL-8 positive (>10 pg/ml) and 10 patients were IL-8 negative (<10 pg/ml). Among the 87 IL-8 positive subjects, 64 patients had no UTI symptoms, while 23 did.

Conclusion: SCI patients should have their urinary IL-8 levels measured on a routine and periodic basis, irrespective of their SCI severity or the presence or absence of UTI symptoms. The timely and effective diagnosis & treatment of UTI can prevent the irreversible complications caused by frequent UTI and resistance to treatment in this group of patients.

Keywords: Interleukin 8 (IL-8), spinal cord injury (SCI), urinary tract infection (UTI).

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2014
Page: [144 - 149]
Pages: 6
DOI: 10.2174/1574891X10666150310152532
Price: $58

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