Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Evaluation of Tetrazole-BasedHydrazone Derivatives Bearing a Pyridine Moiety as Antimicrobial Agents

Author(s): Ahmet Ozdemir, Mehlika Dilek Altıntop, Belgin Sever, Zerrin Canturk, Zafer Asım Kaplancıkl.

Graphical Abstract:


Abstract:

2-[(1-Methyl-1H-tetrazol-5-yl)thio]-N'-[(aryl)methylidene/ethylidene]acetohydrazides were synthesized and investigatedin vitroagainst pathogenic bacteriaand Candidaspecies for their antimicrobial activityusing CLSI broth microdilution method. MTT assay was also carried out to evaluate their cytotoxic effects on NIH/3T3 mouse embryonic fibroblast cell lines.2-((1-Phenyl-1H-tetrazol-5-yl)thio)-N'-(1-(pyridin-3-yl)ethylidene)acetohydrazide can be considered as the most promising antibacterial agent againstEnterococcusfaecalis (ATCC 29212) with a MIC value of 100 µg/mL when compared with chloramphenicol (MIC= 200 µg/mL) and low toxicity against NIH/3T3 cells(IC50>500µg/mL).

Keywords: Antimicrobial activity, cytotoxicity, hydrazone, pyridine, tetrazole.

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Article Details

VOLUME: 12
ISSUE: 8
Year: 2015
Page: [687 - 693]
Pages: 7
DOI: 10.2174/1570180812666150309235217
Price: $58