Modeling Intracellular Ca2+ Transient Induced by Low-Intensity Ultrasound
Intracellular Ca2+ transients have been shown to be induced by ultrasound in various
types of cells and Ca2+ plays an important role in cell recovery after sonoporation. To achieve a
complete understanding of Ca2+ dynamics during insonation and get clues for suitable parameters
of ultrasound to accelerate its clinical application, a new model of ultrasound-induced Ca2+
dynamics has been developed. In the model, effects of ultrasound stimulation on calcium influx
and mobilization have been numerically investigated with an assumed linear relation between the
low-level ultrasound intensity and induced membrane strain density. The modeling results
reproduced the characteristics of elevated intracellular Ca2+ transients induced by ultrasound,
showing a biphasic response of intracellular [Ca2+] for about 3 minutes. Numerical results
suggested that ultrasound intensity should be between 40 and 1200 mW/cm2 to induce
recoverable Ca2+ transients. Stimulation above this intensity range may cause cell damage. This range of intensity changes
with cell types.
Keywords: Calcium influx, calcium transient, modeling, ultrasound.
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