Modeling Intracellular Ca²⁺ Transient Induced by Low-Intensity Ultrasound

Title:Modeling Intracellular Ca²⁺ Transient Induced by Low-Intensity Ultrasound

Volume: 10 Issue: 1

Author(s): Chunmei Yang, Ning Zhang, Yu Guo and Yuanming Feng

Affiliation:

Keywords: Calcium influx, calcium transient, modeling, ultrasound.

Abstract: Intracellular Ca²⁺ transients have been shown to be induced by ultrasound in various types of cells and Ca²⁺ plays an important role in cell recovery after sonoporation. To achieve a complete understanding of Ca²⁺ dynamics during insonation and get clues for suitable parameters of ultrasound to accelerate its clinical application, a new model of ultrasound-induced Ca²⁺ dynamics has been developed. In the model, effects of ultrasound stimulation on calcium influx and mobilization have been numerically investigated with an assumed linear relation between the low-level ultrasound intensity and induced membrane strain density. The modeling results reproduced the characteristics of elevated intracellular Ca²⁺ transients induced by ultrasound, showing a biphasic response of intracellular [Ca²⁺] for about 3 minutes. Numerical results suggested that ultrasound intensity should be between 40 and 1200 mW/cm² to induce recoverable Ca²⁺ transients. Stimulation above this intensity range may cause cell damage. This range of intensity changes with cell types.

Cite this article as:

Yang Chunmei, Zhang Ning, Guo Yu and Feng Yuanming, Modeling Intracellular Ca²⁺ Transient Induced by Low-Intensity Ultrasound, Current Bioinformatics 2015; 10 (1) . https://dx.doi.org/10.2174/157489361001150309142335