Neddylation Pathway as a Novel Anti-cancer Target: Mechanistic Investigation and Therapeutic Implication
Protein neddylation, a newly characterized posttranslational modification that adds the ubiquitin-like
molecule NEDD8 to substrates, modulates important biological processes, whereas dysfunction of neddylation
may cause several serious diseases, such as cancer. Inhibition of neddylation pathway has emerged as a promising
anticancer strategy, as evidenced by development of the NEDD8-activating enzyme (NAE) inhibitor MLN4924.
Due to its potent anti-cancer efficacy and well-tolerated toxicity, MLN4924 has been evaluated in multiple Phase I
clinical trials for solid tumors and hematologic malignancies. Recently, accumulating evidences indicate that
neddylation pathway also plays a pivotal role in the regulation of multiple processes of tumor microenvironment
(TME), such as tumor angiogenesis and the function of immune cells. In this review, we briefly summarize the
latest progresses in this field and highlight neddylation pathway as an attractive therapeutic target against human cancer.
Keywords: Angiogenesis, apoptosis, autophagy, neddylation, Cullin-Ring ligase, MLN4924, NEDD8-activating enzyme, senesence.
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