Cocaine Dependence and Stroke: Pathogenesis and Management

Author(s): Antonio Siniscalchi, Antonello Bonci, Nicola Biagio Mercuri, Antonia De Siena, Giovambattista De Sarro, Giovanni Malferrari, Marco Diana, Luca Gallelli.

Journal Name: Current Neurovascular Research

Volume 12 , Issue 2 , 2015

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Abstract:

Cocaine abuse remains a devastating medical problem for our society. Current concepts suggest that both hemorrhagic and ischemic stroke, particularly in young people, can result as a consequence of cocaine exposure. We provide an analysis of mechanisms of injury and a discussion of the pharmacological management of stroke following cocaine use. Preclinical research suggests that the cause of cocaine-mediated stroke is multifactorial and involves vasospasm, changes in cerebral vasculature, and platelet aggregation. We suggest that drugs able to induce vasospastic, thrombogenic, or neurotoxic effects of cocaine could be suitable as therapeutic agents. In contrast caution should be exerted when using anti-platelet and thrombolytic agents in cocaine users with stroke.

Keywords: Cocaine, hemorrhagic stroke, ischemic stroke, antineurotoxic agents, antithrombogenic agents, antivasospastic agents.

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Article Details

VOLUME: 12
ISSUE: 2
Year: 2015
Page: [163 - 172]
Pages: 10
DOI: 10.2174/1567202612666150305110144
Price: $58

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