Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157


Potential and Limitations of Intervertebral Disc Endogenous Repair

Author(s): Zhen Li, Marianna Peroglio, Mauro Alini, Sibylle Grad.


Intervertebral disc (IVD) disorders, especially degenerative disc disease, reduce the quality of life, and are short of effective therapy. A new direction for treatment of chronic tissue and organ diseases is to promote regeneration by harnessing endogenous repair mechanisms. In this review, we discuss the potential of endogenous repair in the IVD, the recent findings on endogenous IVD progenitor cells, and stem cell niches involved in IVD endogenous repair. We also highlight the factors which may restrict IVD self-healing. Ultimately, advanced therapeutic attempts to boost endogenous repair in the IVD are discussed, including bioactive factor delivery, gene therapy, activation of endogenous IVD progenitor cells and chemokine mediated stem cell homing

Keywords: Annulus fibrosus, endogenous repair, intervertebral disc, nucleus pulposus, progenitor cells, stem cell niche

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Year: 2015
Page: [329 - 338]
Pages: 10
DOI: 10.2174/1574888X10666150305105114
Price: $58