Amelogenesis consists of various development phases that are tightly controlled by the exquisitely
sequential and reciprocal interactions between tooth epithelium and mesenchyme. Subtle alterations
during this complex physiological and biochemical development events could lead to severe
enamel defects in shape, color and structure. Modulations in microRNA, DNA methylation and chromatin
modifications are emerging as important regulatory mechanisms during tooth development. The
growing field of epigenetic regulations in enamel development provides excellent opportunities to
identify novel enamel-related disease makers and to explore the potential therapeutic methods. The present review will
give an overview in the current research progress in epigenetic regulation events during tooth development with a highlight
in the aspects of enamel formation.
Keywords: Amelogenesis, epigenetics, regeneration, stem cells, tooth development.
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