Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Synthesis of Isoxazole Moiety Containing Thieno[2,3-d]pyrimidine Derivatives and Preliminarily in vitro Anticancer Activity (Part II)

Author(s): Jianping Yong, Canzhong Lu, Xiaoyuan Wu.

Graphical Abstract:


Abstract:

21 new structures of isoxazole-moiety-containing thieno[2,3-d]pyrimidine derivatives(3a~3u) were synthesized for the first time and characterized using IR, 1H NMR, 13C NMR, ESI-MS and elemental analysis techniques. And then their in vitro anticancer activity against lung cancer A549, colorectal HCT116 and breast cancer MCF-7 cell lines was preliminarily evaluated using the MTT method. Among them, most compounds exhibited good to excellent anticancer activity. In particular, 3g, 3j and 3n exhibited a broad spectrum and more potent anticancer activity against A549, HCT116 and MCF-7 cell lines, which can be regarded as the promising anticancer drug-candidates.

Keywords: Anticancer activity, isoxazole moiety, synthesis, thieno[2, 3-d]pyrimidine derivatives.

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Article Details

VOLUME: 15
ISSUE: 9
Year: 2015
Page: [1148 - 1155]
Pages: 8
DOI: 10.2174/1871520615666150305103122
Price: $58