Obesity and its related complications are one of the world’s alarming preventable causes of
tumor , diabetes and cardiovascular diseases. Whereas, medicinal herbs are potential source of therapeutic
drugs. The present study was focused on bioactive secondary metabolites of methanolic extract
from whole plant Hartmannia rosea G. Don. The new compound(1), quercetin 3-O-β-Dallopyranoside-
3″, 6″- diacetate (1), and two known compounds, ursolic acid (2) and gallic acid (3),
were isolated for the first time from Hartmannia rosea G. Don. The structure of isolated new compound
(1), quercetin 3-O-β-D-allopyranoside- 3″, 6″- diacetate was elucidated by using chromatographic and modern
spectroscopic techniques. The cytotoxic activity, anticancer and anti- obesity effects of compound (1) were evaluated
against normal ,(3T3-NIH) and Human Pancreatic cancer cell line (PSN-1). The anti- adipogenic effect on 3T3-L1 cell
line was also evaluated. The tested compound (1) showed no cytotoxicity against normal cells (3T3-NIH) but has moderate
activity against PSN-1 (Human Pancreatic cancer cell line) at a higher dose. However, it showed a pronounced inhibitory
effect against adipogenesis of 3T3-L1 adipocytes. The inhibition of the formation of mature adipocytes indicated that
quercetin 3-O-β-D- allopyranoside- 3″, 6″-diacetate (1) from Hartmannia rosea G. Don. has potential anti-obesity effects
and may be a better alternate of chemical and biochemical agents used to control obesity and related chronic diseases.
However its exact mode of action will further be undertaken.