Current Biotechnology

Pabulo Henrique Rampelotto  
Center of Biotechnology and PPGBCM
Federal University of Rio Grande do Sul
Porto Alegre, RS
Brazil

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Leishmaniasis: History, Evolution of Treatment and the Need for New Drugs

Author(s): Elisama Azevedo Cardoso, Aldo Rodrigues da Silva, Gabriela Cristina de Carvalho, Aline Guerra Manssour Fraga, Maria Leticia de Castro Barbosa, Andre Luis Souza dos Santos, Helena Carla Castro, Viviane Lione.

Graphical Abstract:


Abstract:

Leishmaniasis is defined as a cluster of infectious diseases caused by protozoan parasites of the genus Leishmania. It is recognized worldwide as a major health problem, showing high endemicity in developing countries. The present review details this complex group of neglected diseases, with important clinical spectrum and large epidemiological diversity, and discusses the evolution of leishmaniasis treatment and the urgent need for less toxic, more specific and effective drugs against these parasites. Finally, the value of natural products and synthetic derivatives as rich sources of antileishmanial drug candidates is demonstrated, indicating a promising approach for the development of novel therapeutic alternatives.

Keywords: Antileishmanial drugs, Leishmania, Leishmaniasis, Leishmaniasis treatment, natural products, neglected diseases, thiourea.

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Article Details

VOLUME: 3
ISSUE: 4
Year: 2014
Page: [279 - 288]
Pages: 10
DOI: 10.2174/2211550104666150303231736
Price: $58