Synthesis and Reduction of α-Fluoroacetonitriles

Author(s): Mukesh P. Shewalkar , B. Veera Bhadra Reddy , Devanand B. Shinde .

Journal Name: Letters in Organic Chemistry

Volume 12 , Issue 3 , 2015

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

A scalable approach for the cyanosilation of benzaldehydes and acetophenones using indium trichloride, a versatile, user friendly catalyst is developed. Cyanohydrin trimethylsilyl ethers are converted in the same pot to α-fluorophenyl acetonitriles which are efficiently reduced to their corresponding amines using sodium borohydride in presence of cerium trichloride.

Keywords: Cyanohydrin silyl ether, indium trichloride, α-fluorophenyl acetonitrile, sodium borohydride, cerium trichloride, DAST.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 12
ISSUE: 3
Year: 2015
Page: [222 - 226]
Pages: 5
DOI: 10.2174/157017861203150303114411
Price: $58

Article Metrics

PDF: 26
HTML: 2