Amyloid β Accumulation Assessed with 11C-Pittsburgh Compound B PET and Postmortem Neuropathology

Author(s): Hiroyuki Hatsuta , Masaki Takao , Kenji Ishii , Kiichi Ishiwata , Yuko Saito , Kazutomi Kanemaru , Tomio Arai , Tetsuya Suhara , Hitoshi Shimada , Hitoshi Shinotoh , Akira Tamaoka , Shigeo Murayama .

Journal Name: Current Alzheimer Research

Volume 12 , Issue 3 , 2015

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Abstract:

11C-Pittsburgh compound B (PiB) uptake in PET images is frequently used to analyze β amyloid (Aβ) deposition in living individuals, but its correlation with histologically determined Aβ has not been examined. Six individuals with dementia underwent PiB-PET imaging, and their brains were analyzed neuropathologically (mean interval between imaging and death: 816 days; PiB positive:negative, 3:3; male:female, 3:3; mean age: 84.0 years). PiB uptake (reported as standardized uptake value ratio [SUVR]) was analyzed in 11 cortical regions and 10 subcortical grey matter areas and compared with the Aβ load (% area [the percentage of total area positive for Aβ] and number of neuritic plaques) seen with immunohistochemical staining with an anti-Aβ 11-28 antibody. Two PiB-positive subjects had abundant neuritic plaques and were diagnosed with Alzheimer’s disease (AD). SUVR and % area were strongly correlated in the cortical regions of these subjects (subject 1: r = 0.65, p = 0.03; subject 2: r = 0.80, p = 0.003). The other PiBpositive subject (subject 3) showed focal PiB uptake. In subject 3 and the 3 PiB-negative subjects (subjects 4-6), there was no correlation between regional SUVR and % area or neuritic plaques. PiB uptake was not correlated with Aβ deposition in subcortical regions. High PiB positivity in the cerebral cortex suggests the presence of substantial Aβ deposition and neuritic plaques associated with the pathologic changes of AD. Our results suggest that high cortical SUVR is a reliable marker of AD. Subcortical PiB positivity must be interpreted more carefully.

Keywords: Alzheimer’s disease, amyloid beta protein, autopsy, 11C-Pittsburgh compound B (PiB), positron emission tomography (PET), senile plaques.

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Article Details

VOLUME: 12
ISSUE: 3
Year: 2015
Page: [278 - 286]
Pages: 9
DOI: 10.2174/1567205012666150302155930
Price: $58

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