Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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Targeting the Spindle Assembly Checkpoint for Breast Cancer Treatment

Author(s): Sandra Marques, Joana Fonseca, Patricia M.A. Silva, Hassan Bousbaa.

Graphical Abstract:


Abstract:

Breast cancer is the most common malignancy in women worldwide and the second leading cause of cancer deaths after lung cancer. As in other malignancies, aneuploidy is a common feature of breast cancer and influences its behavior. Aneuploidy has been linked to inappropriate activity of the spindle assembly checkpoint (SAC), a surveillance mechanism that, in normal cells, prevents anaphase onset until correct alignment of all chromosomes at the metaphase is achieved. Interestingly, the widely used anti-microtubule drugs, vinca alkaloids and taxanes, kill cancer cells through chronic arrest in mitosis as a consequence of chronic SAC activation. Deregulated SAC has been reported in breast cancer in many reports and presents an attractive therapeutic strategy. We present here a review of the current knowledge on the SAC defects and the underlying molecular mechanisms in breast cancer, and discuss the potential of SAC components as targets for breast cancer therapies.

Keywords: Aneuploidy, anti-mitotics, breast cancer, gene expression, spindle assembly checkpoint, targeted therapy.

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Article Details

VOLUME: 15
ISSUE: 4
Year: 2015
Page: [272 - 281]
Pages: 10
DOI: 10.2174/1568009615666150302130010
Price: $58