Abstract
The search for novel, effective, and safe psychotropic medications for use in children and adolescents is an ongoing journey. Specifically, several atypical antipsychotics have received FDA indications for use in children and adolescents, although carry the risk of potentially serious side effects such as extrapyramidal symptoms, tardive dyskinesia, weight gain, metabolic syndrome, and symptoms of hyperprolactinemia. Three newer antipsychotics – asenapine, iloperidone, and lurasidone – have been considered by some as alternatives to use in children and adolescents with various psychiatric conditions. However, the data on the use of these medications in this population is limited. We review the current literature regarding the use of these agents in children and adolescents. Although these medications may have similar properties to current agents with approved indications, there is not sufficient evidence at this time to recommend their use in children and adolescents. More research is needed regarding the efficacy, safety, and tolerability of these medications in the pediatric population.
Keywords: Adolescents, antipsychotics, asenapine, children, iloperidone, lurasidone.
Current Psychopharmacology
Title:Safety Profile of the Use of Second Generation Antipsychotics in the Child and Adolescent Population
Volume: 3
Author(s): Michael Shapiro, Mariam Rahmani, Adrienne Eisner and Mathew Nguyen
Affiliation:
Keywords: Adolescents, antipsychotics, asenapine, children, iloperidone, lurasidone.
Abstract: The search for novel, effective, and safe psychotropic medications for use in children and adolescents is an ongoing journey. Specifically, several atypical antipsychotics have received FDA indications for use in children and adolescents, although carry the risk of potentially serious side effects such as extrapyramidal symptoms, tardive dyskinesia, weight gain, metabolic syndrome, and symptoms of hyperprolactinemia. Three newer antipsychotics – asenapine, iloperidone, and lurasidone – have been considered by some as alternatives to use in children and adolescents with various psychiatric conditions. However, the data on the use of these medications in this population is limited. We review the current literature regarding the use of these agents in children and adolescents. Although these medications may have similar properties to current agents with approved indications, there is not sufficient evidence at this time to recommend their use in children and adolescents. More research is needed regarding the efficacy, safety, and tolerability of these medications in the pediatric population.
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Cite this article as:
Shapiro Michael, Rahmani Mariam, Eisner Adrienne and Nguyen Mathew, Safety Profile of the Use of Second Generation Antipsychotics in the Child and Adolescent Population, Current Psychopharmacology 2014; 3 (2) . https://dx.doi.org/10.2174/221155600302150302112302
DOI https://dx.doi.org/10.2174/221155600302150302112302 |
Print ISSN 2211-5560 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5579 |
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Breakthroughs in drug design, development and delivery system for the management of neuro-psychiatric disorders
Neuropsychiatric diseases are one of the main causes of disability, affecting millions of people. Various drugs are used for its treatment, although no effective therapy has been found yet. The blood brain barrier (BBB) significantly complicates drugs delivery to the target cells in the brain tissues. This proposal describes the ...read more
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