Objective: The objective of this study is to determine the increase in the prevalence of
antipsychotic polypharmacy in Dokuz Eylul University Psychotic Disorder Outpatient Unit over a
period of 10 years.
Methods: All accessible records of the patients, examined in the Dokuz Eylul University Psychotic
Disorder Outpatient Unit between 1994 and 2000, and in 2010 were evaluated. Ninety one
schizophrenia patients who had been examined between 1994 and 2000 and 102 schizophrenia
patients who had been examined in 2010 were compared in terms of drug prescription patterns.
Results: The point prevalence of antipsychotic polypharmacy showed a significant difference between two groups
(p=0.022), polypharmacy increased from 32% to 49%. The number of first-generation antipsychotic (FGA) medications
decreased from 46% to 26%, while the number of second-generation antipsychotic (SGA) medications increased from
71% to 99%.
Conclusion: The prevalence of antipsychotic combinations both with other antipsychotics and other psychotropic
medicines increased significantly over a period of 10 years.