Computational Drug Repositioning for Cancer Therapeutics

Author(s): Mingkun Jiao, Gang Liu, Yu Xue, Chunyong Ding.

Journal Name: Current Topics in Medicinal Chemistry

Volume 15 , Issue 8 , 2015

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Abstract:

Due to ever-increasing failure rates, high cost, unsatisfactory safety profile, and limited efficacy associated with anticancer drug development, the repositioning of established non-cancer drugs for new oncology indications has emerged as an increasingly attractive approach to addressing the unmet cancer-related medical need. With the rapid development of bioinformatics, chemoinformatics as well as high-performance computing, drug repositioning is becoming more intentional than ever, and a significant surge of computational approaches has been well established to greatly facilitate drug repositioning for cancer treatment. In this review, we provide a brief overview of recent advances in the computational drug repositioning for anticancer applications with a specific emphasis on repositioning of non-cancer drugs by use of various computational approaches.

Keywords: Anticancer drugs, Cancer therapeutics, Computational drug repositioning, Drug discovery, Drug repositioning, Drug repurposing.

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Article Details

VOLUME: 15
ISSUE: 8
Year: 2015
Page: [767 - 775]
Pages: 9
DOI: 10.2174/1568026615666150302105831
Price: $58

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