Targeting Kruppel-Like Factor 5 (KLF5) for Cancer Therapy

Author(s): Yu Gao, Ye Ding, Haiying Chen, Haijun Chen, Jia Zhou.

Journal Name: Current Topics in Medicinal Chemistry

Volume 15 , Issue 8 , 2015

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Kruppel-like factor 5 (KLF5) belongs to a family of zinc-finger-containing transcription factors which are involved in regulating expression of a wide range of genes, thereby affecting diverse cellular functions. The activities of KLF5 are regulated by multiple signaling pathways including Wnt, Ras, TGFβ, Hippo, Notch, retinoid acid receptor, and hormone receptors. The expression of KLF5 is frequently abnormal in human cancers and the functions of KLF5 are context dependent. Accumulating evidence suggests that KLF5 represents a novel therapeutic target for cancer therapy. In this review, we discuss the potential biological functions of KLF5 associated with several key signaling pathways that are relevant to cancer as well as the involvement of KLF5 in various human cancers. We also describe the progress in the discovery and development of small molecules targeting KLF5 as potential therapeutics that may benefit cancer patients. The challenges and future research directions on the drug discovery of KLF5 ligands are also presented.

Keywords: Kruppel-like factor 5 (KLF5), Transcription factors, Signaling pathways, Cancer therapeutics, KLF5 ligands, Drug discovery.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 15
ISSUE: 8
Year: 2015
Page: [699 - 713]
Pages: 15
DOI: 10.2174/1568026615666150302105052
Price: $58

Article Metrics

PDF: 93
HTML: 5
PRC: 1