Frontiers in Medicinal Chemistry

Volume: 7

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“Frontiers in Medicinal Chemistry” is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. “Frontiers in ...
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Therapeutic Approaches to Liver Fibrosis

Pp. 336-384 (49)

Enrico Maria Zardi

Abstract

The advancements in the molecular pathogenesis and a deeper comprehension of cellular mechanisms of liver fibrosis promise to give new therapeutic approaches to the management of this disease in the future.

Apoptosis, cytokines, oxidants, and inflammosomes play a complex role in favouring or delaying the onset of liver fibrosis; sustained hepatic stellate cell activation and transformation, without forgetting the role of hepatocytes and other complex molecular and cellular mechanisms, are the direction that guides to fibrosis.

Therefore, in this review, after considering the causes of the development of fibrosis as well as the interrelation between molecular and cellular profibrotic mechanisms, we will focus on the part played in counteracting both of these actions by some anti-oxidants and anti-fibrotic molecules such as cytokines, prostacyclin and others.

Further validation in animal studies and confirmation in clinical trials are requested. Some data that are already available from in vitro and animal studies demonstrating the effectiveness of novel approaches to inhibiting or treating liver fibrosis can only offer moderate hope.

Keywords:

Adiponectin, antifibrotic drugs, apoptosis, curcumine, cytokines, extracellular matrix, gene therapy, growth factors, hepatic stellate cells, inhibitors of metalloproteinases, interferon, liver fibrosis, metalloproteinases, N-acetyl-Lcysteine, peroxisome proliferator-activated receptors, prostacyclin, reactive oxygen species, relaxin, thiazolidinediones, transcription factors.

Affiliation:

Università “Campus Bio-Medico” Via Àlvaro del Portillo 200 - 00128 Roma, Italy.