In search of novel potent bioactive compounds, a series of novel maleimide-based thiourea
derivatives containing terpinene structure were designed and synthesized. Their structures were characterized
by IR, MS, NMR, UV-vis and elemental analysis. The preliminary bioassay showed that the
target compounds exhibited a certain fungicidal activity, in which compound 2-methoxyphenyl-Naminoethyl-
terpinene-maleimide-based thiourea 5h exhibited the best inhibitory ratio of 64.2%
against Alternaria solani at the concentration of 50 μg•mL-1. A few of the target compounds showed a certain growth inhibition
activity against rape root (Brassica campestris), in which compound 5h exhibited the best inhibitory ratio of
82.0% (A-class activity level) at the concentration of 100 μg•mL-1. The intermediate 4 exhibited excellent growth inhibitory
ratio of 92.3% (A-class activity level) against rape root at the concentration of 100 μg•mL-1. In addition, the structureantifungal
activity relationship of these compounds was also discussed.
Keywords: α-pinene, α-terpinene-maleic anhydride, fungicidal activity, herbicidal activity, thioureas and synthesis.
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