Synthesis and Biological Activity of N-Aminoethyl-terpinene-maleimidebased Thiourea Compounds

Author(s): Lu-zhi Liu , Jing-ni Liao , Wen-gui Duan , Gui-shan Lin , Fu-hou Lei .

Journal Name: Letters in Organic Chemistry

Volume 12 , Issue 4 , 2015

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Graphical Abstract:


In search of novel potent bioactive compounds, a series of novel maleimide-based thiourea derivatives containing terpinene structure were designed and synthesized. Their structures were characterized by IR, MS, NMR, UV-vis and elemental analysis. The preliminary bioassay showed that the target compounds exhibited a certain fungicidal activity, in which compound 2-methoxyphenyl-Naminoethyl- terpinene-maleimide-based thiourea 5h exhibited the best inhibitory ratio of 64.2% against Alternaria solani at the concentration of 50 μg•mL-1. A few of the target compounds showed a certain growth inhibition activity against rape root (Brassica campestris), in which compound 5h exhibited the best inhibitory ratio of 82.0% (A-class activity level) at the concentration of 100 μg•mL-1. The intermediate 4 exhibited excellent growth inhibitory ratio of 92.3% (A-class activity level) against rape root at the concentration of 100 μg•mL-1. In addition, the structureantifungal activity relationship of these compounds was also discussed.

Keywords: α-pinene, α-terpinene-maleic anhydride, fungicidal activity, herbicidal activity, thioureas and synthesis.

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Article Details

Year: 2015
Page: [283 - 289]
Pages: 7
DOI: 10.2174/1570178612666150226230645
Price: $58

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