A 41-year-old woman with Major Depressive Disorder-Recurrent was treated with
topiramate at 150 mg/day. After this administration, she developed intense pruritus and skin lesions
due to scratching. Consequently, she was weaned off topiramate and the lesions regressed. Pruritus and
cutaneous lesions are extremely rare side effects of topiramate, so we report an interesting case of skin
reaction to this drug.
Keywords: Depression, mood stabilizers, pruritus, side effects, skin disorders, topiramate.
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