Synthesis and In vitro Evaluation of Dibenzoazepine Triazole Derivatives: A Novel Class of Antileishmanial Agents
Maria Aqeel Khan,
M. Iqbal Choudhary,
Fatima Z. Basha.
In the present study, a series of dibenzoazepine triazole derivatives (24-39)
were synthesized and evaluated for their in vitro bioactivities including antiglycation,
antibacterial, DPPH radical scavenging, urease inhibition, antileishmanial and immunomodulatory
activities. The compounds were found to be moderately active only
against leishmania. Within this series, compound 26 was found to be the most active
antileishaminals with IC50 value 37.4 ± 0.4 µM. Structure-activity relationships for
this novel class are discussed.
Keywords: Dibenzoazepine, iminostilbene, antileishmanial, click chemistry, immunomodulatory, triazoles.
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