Aqueous Two-phase Extraction in Downstream Processing

Author(s): M.C Madhusudhan , N. Amrutha , Anupama Rani , KSMS Raghavarao .

Journal Name: Current Biochemical Engineering

Volume 2 , Issue 1 , 2015

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Graphical Abstract:


Aqueous two-phase extraction has been effectively used for the separation and purification of several biological molecules. The main advantages of aqueous two-phase extraction are biocompatibility, scope for continuous operation, process integration and ease of scale up. In downstream processing, aqueous two-phase extraction has found its applications in extraction, purification and concentration of various biomolecules. In this review, some of the applications of aqueous two-phase systemsemployed in downstream processing besides some basic aspects and a few case studies are presented. Some of the recent developments with regard to aqueous two-phase extraction are reviewed and the future prospects are also briefly discussed.

Keywords: Aqueous two-phase extraction, biocompatibility, downstream processing, purification, scale up.

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Article Details

Year: 2015
Page: [39 - 48]
Pages: 10
DOI: 10.2174/2212711902666150224234538

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PDF: 29