Secondary Metabolites Derived from Actinomycetes: Iron Modulation and Their Therapeutic Potential
Anil K. Sharma,
The search for new drugs against fungal infections is a major challenge to current research
in mycotic diseases. Among the different types of drugs prevailing in the market antifungal antibiotics
have an important role in the control of mycotic diseases. However the need for new, safe and more
effective antifungal is a major challenge to the pharmaceutical industry today, especially with the
increase in opportunistic infections in the immune-compromised host. Actinomycetes have occupied a
prominent position in the pharmaceutical industry for their seemingly unlimited capacity to produce
secondary metabolites. The use of Actinomycetes as an anti fungal agent in the past is mostly
responsible for its popularity with antibiotic research today. Considering the immense potential of these Actinomycetes in
the discovery of novel lead compounds and for exploitation in pharmaceutical, agriculture and other industrial
applications, current review discusses about secondary metabolites derived from Actinomycetes and the iron modulation
for their use as an effective therapeutic agent.
Keywords: Actinomycetes, antibiotics, antifungal, antimicrobial, iron, secondary metabolites.
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