A high throughput and sensitive analytical method for the comprehensive determination of 31
environmental contaminants (10 pharmaceuticals and personal care products, PPCPs; 8 benzotriazole UV stabilizers,
BUVSs; and 13 organophosphorus flame retardants and plasticizers, PFRs) in aqueous sample using solid phase extraction
(SPE) followed by ultra-high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry
(UHPLC-ESI-MS/MS) was developed. The optimized method was applied to aqueous samples and the limits of quantification
(LOQs) ranged from 1.9 to 16 ng L-1 and from 2.3 to 45 ng L-1 in river water and effluent of sewage treatment plant
(STP), respectively. All the correlation coefficients of the calibration curves were equal or greater than 0.99 in the range
of 0.01-10 μg L-1. Oasis HLB (60 mg) cartridge showed the highest recoveries for all the analytes in river water (71-
115%) as well as in wastewater (71-117%) except for dibenzyl phosphate (DBzP) (58%). The intra- and inter-day
repeatabilities were less than 14% at the two spiked levels (100 and 500 ng L-1). The developed method was applied for
the determination of these target compounds in river water and STP effluent collected from Kumamoto, Suya and
Matsuyama, Japan. Of the thirty-one compounds monitored, seventeen were found in one or more samples, especially diclofenac
(DF) and carbamazepine (CBZ) were detected in all the water samples.
Keywords: PPCPs, BUVSs, PFRs, water, UHPLC-MS/MS.
Rights & PermissionsPrintExport