Discovery of Novel Anti-Diabetic Drugs by Targeting Lipid Metabolism

Author(s): Xiu Zhou , Jun Xu , Yuguang Shi , Ji-Ming Ye .

Journal Name: Current Drug Targets

Volume 16 , Issue 12 , 2015

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Abstract:

Accumulation of toxic lipids is the most common etiology of insulin resistance in type 2 diabetes and associated metabolic disorders such as obesity and non-alcoholic fatty liver disease. Understanding of the underlying mechanisms has revealed various opportunities to target key regulators in lipid metabolic pathways for the treatment of metabolic diseases. Here, we review the discovery and development of potential anti-diabetic drugs with primary effects on cellular targets leading to reductions of intracellular lipids in key organs. We will particularly focus on AMPK, SIRT1, PGC-1α, SREBP-1c, ChREBP, ACC, PPARs and HSPs which either stimulate in fatty acid oxidation (energy expenditure) or inhibit de novo lipogenesis.

Keywords: Anti-diabetic drug targets, drug discovery, insulin resistance, lipid metabolism.

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Article Details

VOLUME: 16
ISSUE: 12
Year: 2015
Page: [1372 - 1380]
Pages: 9
DOI: 10.2174/1389450116666150223120829
Price: $58

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