Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157
USA

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MicroRNA Regulation of Embryonic Stem Cell Pluripotency and Differentiation

Author(s): Xin Zhou, Xuedong Zhou, Liwei Zheng.

Abstract:

Embryonic stem cells (ES cells) hold great potential for regenerative medicine. Grasp of the underlying elaborate machinery is required for clinical application. MicroRNAs serve as important post-transcriptional regulators of various normal and pathological processes. Substantial headway has been made in deciphering miRNAs’ roles in establishment, maintenance and exit from pluripotency in ES cells. Here, we summarize current and ongoing research on microRNAs’ roles of pluripotency maintenance and germ layer specification and possible mechanism to script the cell fate.

Keywords: Embryonic stem cell, germ layer specification, microRNA, pluripotency.

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Article Details

VOLUME: 10
ISSUE: 5
Year: 2015
Page: [392 - 397]
Pages: 6
DOI: 10.2174/1574888X10666150220155222
Price: $58