Antioxidant Properties of Melatonin and its Potential Action in Diseases

Author(s): Cigdem Karaaslan, Sibel Suzen.

Journal Name: Current Topics in Medicinal Chemistry

Volume 15 , Issue 9 , 2015

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Abstract:

In recent years, relationship between free radicals and oxidative stress with aging, cancer, atherosclerosis, neurodegenerative disorders, diabetes, and inflammatory diseases became increasingly clear. Confirming the role of oxidants in numerous pathological conditions such as cancer, the antioxidants developed as therapeutics have been proven ineffective. It is well established that melatonin (MLT) and its metabolites are able to function as endogenous free-radical scavengers and broadspectrum antioxidants. Numerous studies also proved the role of MLT and its derivatives in many physiological processes and therapeutic functions, such as the regulation of circadian rhythm and immune functions. The aim of this review is to arouse attention to MLT as a potentially valuable agent in the prevention and/or treatment of some diseases.

Keywords: Antioxidant, Cancer, Diabetes, Immune system, Inflammatory diseases, Melatonin, Neurodegenerative disorders, Radiation.

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Article Details

VOLUME: 15
ISSUE: 9
Year: 2015
Page: [894 - 903]
Pages: 10
DOI: 10.2174/1568026615666150220120946
Price: $58

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