Structural and Modeling Studies on ecto-5’-nucleotidase Aiding in Inhibitor Design

Author(s): Norbert Furtmann, Jurgen Bajorath.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 15 , Issue 1 , 2015

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Abstract:

Ecto-5’-nucleotidase (e5NT) hydrolyzes extracellular nucleotides and contributes to purinergic signaling. e5NT is implicated in a variety of pathological states including immunological diseases and cancer and represents an emerging drug target. Herein, we review structural and computational studies that have helped to better understand ligand binding characteristics and mechanistic features of the enzyme and led to the identification of new classes of e5NT inhibitors.

Keywords: Catalytic mechanism, computational design, Ecto-5’-nucleotidase, inhibitors, virtual screening, x-ray crystallography.

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Article Details

VOLUME: 15
ISSUE: 1
Year: 2015
Page: [34 - 40]
Pages: 7
DOI: 10.2174/1389557515666150219112630

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