The interaction of Mitomycin C with dsDNA was performed with differential
pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) by
using carbon nanotubes modified single-use pencil graphite electrode (CNTs-PGE)
and bare PGE. The passive adsorption process was used to modify the electrode surface
by CNTs and then dsDNA was immobilized onto the modified PGEs by a strong
chemical interaction between the amine groups of dsDNA and the carboxyl groups of
CNTs. The performance of CNT-PGEs was studied by examining the optimum analytical conditions; MC concentration,
interaction time, etc. with voltammetric methods and then impedance method was performed to characterize the modification
of CNTs onto the electrode surface.
Keywords: Biosensor, carbon nanotubes, differantial pulse voltammetry, drug-DNA interaction, electrochemical impedance
spectroscopy, mitomycin C.
Rights & PermissionsPrintExport