Current Women`s Health Reviews

John Yeh  
Harvard Medical School 
Department of Obstetrics and Gynecology
Massachusetts General Hospital
Boston, MA


New Technologies: Non-Hormonal Female Contraception

Author(s): M. Blake Evans, Chon-Hwa Tsai-Morris.

Graphical Abstract:


Since the introduction of hormonal contraception in the 1960s, their popularity has grown exponentially and benefits a large population of reproductive aged women. Currently available options are lacking for women with comorbidities such as hypertension, migraines, lupus, liver pathology, thrombophilias, obesity, etc. Recent studies reveal promising evidence of several non-hormonal contraceptive methods that will be of tremendous benefit to women with these comorbidities. Non-hormonal contraceptive methods under investigation include Phosphodiesterase (PDE) 3/5/9 inhibitors, matrix metalloprotease (MMP) inhibitors, cyclooxygenase-2 inhibitors, prostaglandin E2 receptor antagonists, C31G spermicide, SGK/AKT, polidocanol foam, quinacrine pellets, proprotein convertase 6 inhibitors, interleukin 11 (IL-11), leukemia inhibitory factor (LIF), and Juno-Izumo binding vesicles. These methods would provide new options for female contraception particularly for those women who can’t use hormonal contraception.

Keywords: Female contraception, non-hormonal.

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Year: 2014
Page: [72 - 81]
Pages: 10
DOI: 10.2174/1573404811666150214004553
Price: $58