Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Structure, DNA Binding and Cytotoxicity Studies of [Cu(D-glu)(phen)(H2O)]•NO3•2H2O

Author(s): Ling Liu, Jie Mou, Youguang Zheng, Tonghui Huang, Shuaishuai Wang, Yi Liu.

Graphical Abstract:


Abstract:

A new complex [Cu(D-glu)(phen)(H2O)]·NO3·2H2O 1 (D-glu = D-glutamic acid, phen = 1,10-phenanthroline) was synthesized and identified by IR spectroscopy and single-crystal X-ray diffraction. Fluorescence studies showed that 1 exhibited stronger intercalative interaction to CT-DNA as compared to known complex [Cu(L-glu)(phen)(H2O)]·NO3·2H2O 2. Both complexes inhibited the growth of MCF-7 cells with the IC50 values of 0.141 μmol·L-1 and 0.126 μmol·L-1 for complex 1 and 2, respectively. The complexes were 20 times more active than the amino acid - free complex [Cu(phen)(H2O)2(NO33)] · NO3 3.

Keywords: [Cu(D-glu)(phen)(H2O)] • NO3 • 2H2O, crystal structure, fluorescence studies, cytotoxic studies.

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Article Details

VOLUME: 12
ISSUE: 8
Year: 2015
Page: [640 - 642]
Pages: 3
DOI: 10.2174/1570180812666150213230711
Price: $58