Proteins as Alternate Targets of Enediynes
Hussam M. Bdour,
From various studies it is now clear that in addition to nucleic acids, enediynes
also target other biomolecules, the most prominent of which are the proteins.
Since a major portion of currently available drug targets are proteins (enzymes and receptors), this aspect
of enediyne chemistry has opened a new window for further exploitation. Newer enediyne-based therapeutics
targeting proteins may be possible to design. Moreover, the toxicity of the natural enediynes may
arise from the non-selective protein cleavages. Substantial progress has been made to understand the nature
of interaction between enediynes and proteins. This article is an attempt to discuss the developments
in this area.
Keywords: Bergman cyclization, cycloaromatization, diradicals, dna, enediynes, protein.
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