This short review summarises the most important results obtained during the past decade in
the field of palladium catalysed aminocarbonylation. In this reaction, using amines as N-nucleophiles,
the carbonylation of enol-triflates/aryl-triflates or their synthetic surrogates, alkenyl halides/aryl halides
takes place resulting in the formation of unsaturated carboxamides or aryl carboxamides. In the
latter case, 2-ketocarboxamides are also formed via double carbon monoxide insertion. The efficiency
of aminocarbonylation is illustrated by several high-yielding syntheses including transformation of
both simple model substrates and skeletons of biological importance. As green chemistry aspects of
this reaction, the ambient conditions, high activity, low catalyst loading, the possibility of tuning selectivities and high
functional group tolerance should be mentioned.
Keywords: Amide, carbonylation, palladium, chemoselectivity, environmentally benign reaction.
Rights & PermissionsPrintExport