Hepatocellular Carcinoma Outside of the Milan Criteria
C. Anne Doughtie,
Michael E. Egger,
Kean O. Feyzeau,
Christopher M. Jones,
Michael R. Marvin,
Kelly M. McMasters,
Eric G. Davis.
Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths worldwide and the incidence and mortality
rate are nearly identical in the United States. The Milan Criteria established thresholds of tumor size and number as predictors
of optimum overall survival with liver transplant and changed the definitive treatment for HCC. However, after
nearly two decades of experience two problems have emerged: post-transplant recurrence continues and an increasing
number of patients exceed these size criteria. While tumor burden is an important prognostic factor, it remains limited in
its ability to fully define underlying tumor biology and predict recurrence after transplant. Recognizing that tumor size
and number are merely surrogate markers of tumor behavior, multiple centers have sought to expand these criteria and
consider other oncologic and radiologic factors. Response to locoregional therapies may help to better determine tumor
behavior and predict which patients might recur after transplant. Emerging analysis of tumor biology and genetics may
also help to predict recurrence more accurately than size alone. Future selection of transplant candidates may be via molecular
profiling or chronological imaging changes to identify those patients who would benefit most from the finite number
of available grafts, while limiting recurrence after transplant.
Keywords: Hepatocellular carcinoma, transplant, prognosis.
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