Synthesis of (S)-(+)-2-(N-benzylamino)butan-1-ol from its Schiff Base by Catalytic Hydrogenation over Palladium

Author(s): Laszlo Hegedus, Sandor Miskolczi, Gyorgy Bansaghi, Edit Szekely, Ferenc Faigl.

Journal Name: Current Green Chemistry

Volume 2 , Issue 3 , 2015

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Abstract:

A chiral 1,2-amino alcohol derivative, (S)-(+)-2-(N-benzylamino)butan-1-ol (BAB), was synthesized from its Schiff base by catalytic hydrogenation over palladium on carbon, in various solvents (toluene, methanol, hexane, dichloromethane, tetrahydrofuran, ethyl acetate), under mild conditions (room temperature, atmospheric pressure). Preparation of the Schiff base was also optimized. This compound is a resolving agent for preparing optically active, practically important cyclopropanecarboxylic acids.

Keywords: Heterogeneous catalysis, hydrogenation, palladium, supported metal catalyst.

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Article Details

VOLUME: 2
ISSUE: 3
Year: 2015
Page: [312 - 318]
Pages: 7
DOI: 10.2174/2213346102666150211001310
Price: $58

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