New Missions for an Old Agent: Granulocyte-Colony Stimulating Factor in the Treatment of Stroke Patients

Author(s): Ihsan Solaroglu, Murat Digicaylioglu, G. Evren Keles, John H. Zhang.

Journal Name: Current Medicinal Chemistry

Volume 22 , Issue 10 , 2015

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Abstract:

Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, antioxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.

Keywords: Granulocyte-colony stimulating factor, neuroprotection, stroke, treatment.

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Article Details

VOLUME: 22
ISSUE: 10
Year: 2015
Page: [1302 - 1309]
Pages: 8
DOI: 10.2174/0929867322666150209153606
Price: $58

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